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Fig. 7 | Molecular Brain

Fig. 7

From: Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development

Fig. 7

Cortactin deacetylation is important for dendrite growth and Golgi polarization in vivo. Neurons expressing acetylation mimetic form of cortactin were defective in dendrite development and Golgi polarization in vivo.a Phenotype of cortactin acetylation mimetic mutant overexpressing neurons. Scale bar, 20 μm. b Quantification of the number of primary dendrites in control and cortactin mutant overexpressing neurons (control, n = 32; cortactin 9KQ, n = 28). c, d Acetylation mimetic mutant of cortactin expressing neurons does not polarize dendritic Golgi. Venus-GalT2 was localized in Golgi apparatus. d Graph represents the percentage of neurons with dendritic Golgi (control, n = 211; cortactin 9KQ, n = 188). *p < 0.05, ***p < 0.001 by two-tailed Student’s t-test. The symbol # represents the number. Error bar means ± S.D. in all graphs

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