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Fig. 1 | Molecular Brain

Fig. 1

From: Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth

Fig. 1

Specific depletion of Lepr in nestin-expressing progenitor cells leads to obesity. a No obvious phenotype of the Shh-Cre;Leprflox/flox(Shh-cKO) mice compared with control littermates examined at P35 or P70, as indicated (upper panel). No difference in body weight of the Shh-cKO mice compared with control littermates examined during the first 10 weeks after birth (lower panel). bNes-Cre;Leprf/f (Nes-cKO) mice display severe obesity (upper panel) at P35 or P70 and a significant increase of body weight from week 5 compared with control littermates (lower panel). (n ≥ 10 mice per group)

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Molecular Brain

ISSN: 1756-6606