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Fig. 6 | Molecular Brain

Fig. 6

From: Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth

Fig. 6

Depletion of Lepr in nestin-expressing cells does not affect the fate of NPCs in the dentate gyrus during early postnatal development. a Experimental scheme. Nes-cKO mice or control littermates received BrdU twice daily between P7 and P15 and were sacrificed at P35. b-d Representative images showing BrdU-expressing cells colocalizing with NeuN (b), OLIG2 (c) or GFAP (d) in the dentate gurus by immunostaining of samples from control or Nes-cKO mice. Shown to the right is the quantification of the percentage of the BrdU+ cells displaying co-localization with NeuN, OLIG2, or GFAP (n = 4 mice per group). DG, dentate gurus. Scale bars, 100 μm. ns, no significant; Student’s two-tailed, unpaired t-test. Error bars indicate s.e.m.

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