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Fig. 3 | Molecular Brain

Fig. 3

From: TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion

Fig. 3

Effects of TMEM175 overexpression on long-term recovery of neurological function after MCAO/R in rats. a A typical swim path of rats in the Morris water maze at 25 d after MCAO/R. b Time to reach the submerged platform in the Morris water maze at 22–25 d after MCAO/R (MCAO/R vs. sham, *p = 0.0012, Day 22; *p = 0.0317, Day 23; *p = 0.0147, Day 24; *p = 0.0059, Day 25; Vector vs. Over-TMEM175, NS, no significant). c Rotarod test (MCAO/R vs. sham, ****p < 0.0001, Day 22–25; Vector vs. Over-TMEM175, *p = 0.0359, Day 7; *p = 0.0263, Day 14). d Adhesive-contact time (MCAO/R vs. sham, ****p < 0.0001, Day 3, Day5, Day7, Day14; Vector vs. Over-TMEM175, *p = 0.0268, Day 7; *p = 0.0407, Day 14). e Adhesive-removal time (MCAO/R vs. sham, ****p < 0.0001, Day 3, Day5, Day7, Day14; Vector vs. Over-TMEM175, *p = 0.0268, Day 7; *p = 0.0407, Day 14)

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Molecular Brain

ISSN: 1756-6606