Skip to main content
Fig. 6 | Molecular Brain

Fig. 6

From: TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion

Fig. 6

TMEM175 overexpression reverses lysosomal function in neurons exposed to OGD/R. a Fluorescent photographs of acridine-orange (AO) staining of neuronal cultures treated with OGD/R, bafilomycin A1 (100nM), or transfection of TMEM175-overexpression plasmid. b Relative enzymatic activity of CTSB and CTSD in neurons (OGD/R vs. control, ****p < 0.0001; Vector vs. Over-TMEM175, ****p < 0.0001). c Fluorescent photographs of LysoSensor Green staining of neuronal cultures (OGD/R vs. control, **p = 0.001; Vector vs. Over-TMEM175, **p = 0.0082). d Schematic representation of potential mechanisms of TMEM175 actions in cerebral I/R injury

Back to article page

Molecular Brain

ISSN: 1756-6606