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Fig. 1 | Molecular Brain

Fig. 1

From: Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice

Fig. 1

miRNA expression and behaviour in miR-22-deficient mice. (a-e) Graphs show relative expression of miR-22 and a selection of other brain cell type-enriched miRNAs in miR-22 mutant mice. a Graph confirms gene dose-related reductions of miR-22 in the hippocampus of miR-22+/− and miR-22−/− compared to wildtype (wt) mice. b-f. Expression of neuron-enriched miRNAs (miR-124a and − 134), microglial (miR-150, miR-342) and astrocyte (miR-29a) were unaltered in miR-22 mutant mice. g-i Graphs show expression of a selection of inflammation-related transcripts in the mutant mice. Note, slightly elevated expression of P2X7 which is a validated target of miR-22. j, k Graphs show miR-22-deficient mice perform normally in tests of coordination (rotarod) and anxiety (elevated plus maze). *P < 0.05 and ***P < 0.01 (n = 6/group; 3 males and 3 females)

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