Fig. 3

Status epilepticus and acute histological outcomes in miR-22-deficient mice. a Representative recordings of electrographic seizures (pseudocolour transforms of original EEG) during status epilepticus in mir-22^+/− (middle trace) and miR-22^−/− (bottom trace) mice compared to a wildtype (top trace) control. b-e Graphs show EEG total power and amplitude during the 40 min period from kainic acid administration to lorazepam and the 60 min period thereafter. Blue dots indicate male mice, red dots indicate female mice (n = 7–10/group). f-i. Representative photomicrographs of the hippocampus of mice 72 h after status epilepticus. There were no differences in acute neuronal loss, astrogliosis, microgliosis or interneuron (parvalbumin) staining