Fig. 4

Epilepsy phenotype in miR-22-deficient mice. a Graphic shows individual mouse (1–6) daily seizure counts and summative graphs showing spontaneous seizures during 14 days recording in male wildtype (wt) and miR-22^−/− mice. b Graph showing numbers of spontaneous recurrent seizures during the 14 days recording in which miR-22^−/− mice display an elevated number of spontaneous seizures compared to wildtype mice. c Average time in seizures per day was increased in mice lacking miR-22 and average spontaneous seizure duration is longer in miR-22^−/− mice. d Total seizure counts for the two groups over the 14 days monitoring. *P < 0.05 (n = 6/group). e Representative traces of spontaneous seizures captured by telemetry EEG in a wildtype and miR-22^−/− mouse. Note the longer duration of seizure typical to miR-22-deficient mice