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Fig. 1 | Molecular Brain

Fig. 1

From: LncRNA MALAT1 facilitates inflammasome activation via epigenetic suppression of Nrf2 in Parkinson’s disease

Fig. 1

MPTP-induced PD mice show activation of inflammasome (a) Rotarod assay of the mice intraperitoneally treated with MPTP. Movement time: latency of an animal dropping off from rotating rod (b) The number of TH+ positive neurons was decreased in PD mouse brains by immunohistochemical analysis. c The expression level of TH in the brains of PD mice was analysed by western blot analysis. d The immunohistochemical analysis of IBA-1 in the microglial cells in the PD mice. e The mRNA levels of TNF-α, IL-1β and IL-18 were measured in PD mice qPCR. f The mRNA level of MALAT1 was determined in PD mice by qPCR. g Western blot analysis of cleaved caspase 1, NLRP3, ASC and Nrf2 levels in PD mice. The data in the graph are presented as the means ±SD as the relative levels from three replications. n = 6 for control group, n = 8 for PD group. *p < 0.05, **p < 0.01

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Molecular Brain

ISSN: 1756-6606