Fig. 7

MALAT1 knockdown protects neuroinflammation in an MPTP-induced PD mouse model. After the establishment of MPTP-induced PD mouse model, siMALAT1 was injected to knockdown MALAT1 mice. siNC was used as control. a Expression of MALAT1 was quantified by RT-qPCR in the MPTP-induced PD mice with different treatments (b) Rotarod assay of the MPTP-induced PD mice with different treatments. n = 10 for each group. Immunohistochemical analysis of TH (c) and IBA-1 (d) in SN tissues from the MPTP-induced PD mice with different treatments. e Secretion of cytokines, including TNF-α, IL-1β and IL-18 were measured in MPTP-induced PD mice with different treatments by RT-qPCR. f Western blot analysis of the cleaved caspase 1, NLRP3, ASC and Nrf2 levels in the MPTP-induced PD mice with different treatments. The data in the graph are presented as the means ±SD as the relative levels from three replications. *p < 0.05, **p < 0.01. a Cell ap