Fig. 7
From: mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease
Genetic ablation of mGluR5 modulate REST/NRSF and SNAP-25 protein levels in BACHD mice. Representative western blots and quantification of fold change in protein levels of REST/NRSF and SNAP25 with the corresponding loading controls in hippocampal lysates from wild-type (WT), mGluR5−/−, BACHD and BACHD/ mGluR5−/− mice at (a) 6 and (b) 12 months of age. REST/NRSF was normalized to vinculin and SNAP-25 was normalized to actin (n = 4–6 to each group). Values represent mean ± SEM and are expressed as a fraction of WT value. * denotes P < 0.05 and statistical significance was assessed by one-way ANOVA and Fisher’s LSD multiple comparisons