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Fig. 4 | Molecular Brain

Fig. 4

From: Overexpression of Slit2 decreases neuronal excitotoxicity, accelerates glymphatic clearance, and improves cognition in a multiple microinfarcts model

Fig. 4

Overexpression of Slit2 increases peri-infarct GABAergic activity. a Immunoexpression of the GABAergic interneuron marker GAD67 and the neuronal marker Neun in peri-infarct areas (40 ×). b Immunofluorescence staining of VGAT in peri-infarct areas (63 ×, zoomed in 3). c Comparison of GABAergic interneuron number and mean VGAT immunofluorescence intensity among sham and MI groups of WT and Slit2-Tg mice. d Chemiluminescence imaging of GAD67 and GAPDH, or VGAT and GAPDH in the peri-infarct area. e Comparison of GAD67/GAPDH and VGAT/GAPDH expression ratios in the peri-infarct area among sham and MI groups of WT and Slit2-Tg mice. Each dataset is expressed as mean ± SD. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001. n = 6 mice

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Molecular Brain

ISSN: 1756-6606