Skip to main content
Fig. 3 | Molecular Brain

Fig. 3

From: D1 receptors in the anterior cingulate cortex modulate basal mechanical sensitivity threshold and glutamatergic synaptic transmission

Fig. 3

Modulation of AMPAR eEPSCs by D1R agonist SKF 81297. a I: Averaged sample traces of AMPAR eEPSCS and time course of SKF 81297 30 μM application. II: averaged and normalized data for time course of SKF 81297 30 μM application (n = 10/7 mice). b I: Averaged sample traces of AMPAR eEPSCS and time course of SKF 81297 10 μM application. II: averaged and normalized data for time course of SKF 81297 10 μM (n = 8/5mice). c I: EPSCs were significantly reduced by SKF 81297 30 μM compared with baseline transmission and washout phase (one-way ANOVA, F2,27 = 31.22, p < 0.001). II: EPSCs were significantly reduced by SKF 81297 10 μM compared with baseline transmission and washout phase (one-way ANOVA, F2,21 = 4.27, p = 0.02). d No difference in the inhibition of AMPAR mediated eEPSCs by SKF 81297 30 μM and 10 μM, (t-test, t13 = 0.62, p = 0.506). e I: Averaged sample traces and averaged and normalized data (n = 7/4mice). II: SKF81297 30 μM did not produce significant change in baseline transmission in presence of GDP-beta-S 2 mM in pipette (paired t-test, t12 = 0.43, p = 0.6831). f I: Averaged sample traces and averaged and normalized data (n = 8/6 mice). II: No significant difference in PPR following SKF 81297 30 μM application when compared with baseline responses (paired t-test, t7 = 0.52, p = 0.62). *p < 0.05, ***p < 0.001

Back to article page