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Table 1 Electrophysiology studies characterizing D1R modulation of basal AMPAR mediated transmission. D1R agonist modulation of basal AMPAR mediated currents

From: D1 receptors in the anterior cingulate cortex modulate basal mechanical sensitivity threshold and glutamatergic synaptic transmission

D1R agonist Species AMPAR current Result Neuron Type Synaptic locus Region Reference
SKF 81297 (30 μM)
DA (30 μM)
Rat eEPSC
eEPSC, mEPSC
Inhibit
//
Magnocellular
//
Presynaptic
//
BF
//
[39]
SKF 81297 (30 μM) Rat eEPSC Inhibit Cholinergic Presynaptic BF [40]
SKF 81297 (1 μM) Rat eEPSC Inhibit Pyramidal layer V Presynaptic PFC [41]
SKF 38393 (10 μM) Rat eEPSC Enhance Pyramidal Layer II/III Postsynaptic PFC [29]
DA (250 nm-5 μM) Monkey eEPSC Inhibit Pyramidal layer III Undetermined PFC [42]
SKF 81297 (1 μM) Rat eEPSC Enhance Pyramidal Layer II/lll Postsynaptic PFC [43]
SKF 81297 (5 μM) Mice eEPSC No effect Pyramidal PFC [28]
DA (50 μM)
SKF 81297 (10 μM)
Mice
//
sEPSC
//
Enhance
//
D1R+ neurons
//
Presynaptic
//
Dorsal Striatum
//
[44]
SKF 81297 (1 μM) Rat Kainite EPSC   Cultured MSN   Striatum [45]
SKF 38393 (10 M) Rat AMPA EPSC Enhance MSN Postsynaptic Dorsal Striatum [46]
SKF 38393 (5 μM)
//
Rat
//
eEPSC
glutamate EPSC
Enhance
No effect
MSN
//

Striatum [47]
DA (75 μM)
SKF 81297 (30 μM)
SKF 38393 (100 μM)
Rat
//
//
eEPSP
//
//
Inhibit
No effect
LTD
Field & whole cell
//
//
Presynaptic NAc
//
//
[48]
DA (50 μM)
SKF 38393 (10 μM)
Mice eEPSC
//
Inhibit
//
MSN
//
Postsynaptic
//
NAc
//
[49]
SKF 81297 (5 μM) Mice Kainate EPSC enhance MSN Postsynaptic Neostriatum [50]
SKF 81297 (5 μM) Chicken mEPSC No effect Pyramidal layer II/III
Motoneurons
ACC [51]
SKF 38393 (10 μM) Mice glutamate EPSC Enhance   Embryonic [52]
  1. Studies were selected based on activity mediated by D1R pharmacological agonists and antagonist, BF Basal forebrain, PFC Prefrontal cortex, NAc Nucleus Accumbens, ACC Anterior Cingulat Cortex, eEPSC Stimulation evoked excitatory postsynaptic current, mEPSC miniature excitatory postsynaptic potential, Kainate EPSC and AMPA EPSC EPSC Evoked by application of kainite or AMPA, LTD Long-term Depression, MSN Medium spiny neuron