Table 1 Electrophysiology studies characterizing D1R modulation of basal AMPAR mediated transmission. D1R agonist modulation of basal AMPAR mediated currents
| D1R agonist | Species | AMPAR current | Result | Neuron Type | Synaptic locus | Region | Reference |
|---|---|---|---|---|---|---|---|
|
SKF 81297 (30 μM) DA (30 μM) | Rat |
eEPSC eEPSC, mEPSC |
Inhibit // |
Magnocellular // |
Presynaptic // |
BF // | [39] |
| SKF 81297 (30 μM) | Rat | eEPSC | Inhibit | Cholinergic | Presynaptic | BF | [40] |
| SKF 81297 (1 μM) | Rat | eEPSC | Inhibit | Pyramidal layer V | Presynaptic | PFC | [41] |
| SKF 38393 (10 μM) | Rat | eEPSC | Enhance | Pyramidal Layer II/III | Postsynaptic | PFC | [29] |
| DA (250 nm-5 μM) | Monkey | eEPSC | Inhibit | Pyramidal layer III | Undetermined | PFC | [42] |
| SKF 81297 (1 μM) | Rat | eEPSC | Enhance | Pyramidal Layer II/lll | Postsynaptic | PFC | [43] |
| SKF 81297 (5 μM) | Mice | eEPSC | No effect | Pyramidal | – | PFC | [28] |
|
DA (50 μM) SKF 81297 (10 μM) |
Mice // |
sEPSC // |
Enhance // |
D1R+ neurons // |
Presynaptic // |
Dorsal Striatum // | [44] |
| SKF 81297 (1 μM) | Rat | Kainite EPSC | Cultured MSN | Striatum | [45] | ||
| SKF 38393 (10 M) | Rat | AMPA EPSC | Enhance | MSN | Postsynaptic | Dorsal Striatum | [46] |
|
SKF 38393 (5 μM) // |
Rat // |
eEPSC glutamate EPSC |
Enhance No effect |
MSN // |
– – | Striatum | [47] |
|
DA (75 μM) SKF 81297 (30 μM) SKF 38393 (100 μM) |
Rat // // |
eEPSP // // |
Inhibit No effect LTD |
Field & whole cell // // | Presynaptic |
NAc // // | [48] |
|
DA (50 μM) SKF 38393 (10 μM) | Mice |
eEPSC // |
Inhibit // |
MSN // |
Postsynaptic // |
NAc // | [49] |
| SKF 81297 (5 μM) | Mice | Kainate EPSC | enhance | MSN | Postsynaptic | Neostriatum | [50] |
| SKF 81297 (5 μM) | Chicken | mEPSC | No effect |
Pyramidal layer II/III Motoneurons | – | ACC | [51] |
| SKF 38393 (10 μM) | Mice | glutamate EPSC | Enhance | – | Embryonic | [52] |