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Table 1 Electrophysiology studies characterizing D1R modulation of basal AMPAR mediated transmission. D1R agonist modulation of basal AMPAR mediated currents

From: D1 receptors in the anterior cingulate cortex modulate basal mechanical sensitivity threshold and glutamatergic synaptic transmission

D1R agonist

Species

AMPAR current

Result

Neuron Type

Synaptic locus

Region

Reference

SKF 81297 (30 μM)

DA (30 μM)

Rat

eEPSC

eEPSC, mEPSC

Inhibit

//

Magnocellular

//

Presynaptic

//

BF

//

[39]

SKF 81297 (30 μM)

Rat

eEPSC

Inhibit

Cholinergic

Presynaptic

BF

[40]

SKF 81297 (1 μM)

Rat

eEPSC

Inhibit

Pyramidal layer V

Presynaptic

PFC

[41]

SKF 38393 (10 μM)

Rat

eEPSC

Enhance

Pyramidal Layer II/III

Postsynaptic

PFC

[29]

DA (250 nm-5 μM)

Monkey

eEPSC

Inhibit

Pyramidal layer III

Undetermined

PFC

[42]

SKF 81297 (1 μM)

Rat

eEPSC

Enhance

Pyramidal Layer II/lll

Postsynaptic

PFC

[43]

SKF 81297 (5 μM)

Mice

eEPSC

No effect

Pyramidal

–

PFC

[28]

DA (50 μM)

SKF 81297 (10 μM)

Mice

//

sEPSC

//

Enhance

//

D1R+ neurons

//

Presynaptic

//

Dorsal Striatum

//

[44]

SKF 81297 (1 μM)

Rat

Kainite EPSC

 

Cultured MSN

 

Striatum

[45]

SKF 38393 (10 M)

Rat

AMPA EPSC

Enhance

MSN

Postsynaptic

Dorsal Striatum

[46]

SKF 38393 (5 μM)

//

Rat

//

eEPSC

glutamate EPSC

Enhance

No effect

MSN

//

–

–

Striatum

[47]

DA (75 μM)

SKF 81297 (30 μM)

SKF 38393 (100 μM)

Rat

//

//

eEPSP

//

//

Inhibit

No effect

LTD

Field & whole cell

//

//

Presynaptic

NAc

//

//

[48]

DA (50 μM)

SKF 38393 (10 μM)

Mice

eEPSC

//

Inhibit

//

MSN

//

Postsynaptic

//

NAc

//

[49]

SKF 81297 (5 μM)

Mice

Kainate EPSC

enhance

MSN

Postsynaptic

Neostriatum

[50]

SKF 81297 (5 μM)

Chicken

mEPSC

No effect

Pyramidal layer II/III

Motoneurons

–

ACC

[51]

SKF 38393 (10 μM)

Mice

glutamate EPSC

Enhance

 

–

Embryonic

[52]

  1. Studies were selected based on activity mediated by D1R pharmacological agonists and antagonist, BF Basal forebrain, PFC Prefrontal cortex, NAc Nucleus Accumbens, ACC Anterior Cingulat Cortex, eEPSC Stimulation evoked excitatory postsynaptic current, mEPSC miniature excitatory postsynaptic potential, Kainate EPSC and AMPA EPSC EPSC Evoked by application of kainite or AMPA, LTD Long-term Depression, MSN Medium spiny neuron