Fig. 3
From: Fear response-based prediction for stress susceptibility to PTSD-like phenotypes
Similar anxiety levels but increased fear responses from susceptible mice. a Freezing responses to CS during fear conditioning are similar among groups (two-way repeated measures ANOVA). b-c Susceptible mice exhibit enhanced fear generalization. b Susceptible mice show increased freezing responses to the novel cue compared with those of resilient and unstressed mice (left) and increased freezing responses to the CS compared with those of unstressed mice but not resilient ones (right). c Generalization indices of susceptible mice are significantly higher than those of the other groups. **P < 0.01, ****P < 0.0001, ####P < 0.0001 (one-way ANOVAs). d Fear extinction is significantly impaired in susceptible mice. ****P < 0.0001, ####P < 0.0001 (two-way repeated measures ANOVA, Tukey’s test). e Susceptible mice exhibit increased freezing responses 24 h after memory extinction compared with those of other groups. ****P < 0.0001, ####P < 0.0001 (one-way ANOVA). f All groups exhibit comparable anxious behaviors in the EPM for times spent in open arms (left), numbers of entries into open arms (middle), and the travel distance (right) (one-way ANOVAs). Plots show means ± SEMs