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Fig. 4 | Molecular Brain

Fig. 4

From: Fear response-based prediction for stress susceptibility to PTSD-like phenotypes

Fig. 4

Stress exposure results in increased freezing in the ITI during fear conditioning only in susceptible mice. a Susceptible mice exhibit enhanced freezing 60 s before and 60 s after CS presentation compared with that by unstressed and resilient mice. Those data are mean values of freezing responses from 4 trials of 60 s before and 60 s after CS-US pairing. US was presented and co-terminated with CS. ****P < 0.0001, ####P < 0.0001 (two-way repeated measures ANOVA, Tukey’s test). b Susceptible mice exhibit increased freezing responses compared with those by unstressed and resilient mice in the ITI. ***P < 0.001, ###P < 0.001 (two-way repeated measures ANOVA, Tukey’s test). c Stressed mice exhibit comparable freezing responses in ITI to those by unstressed control mice. ns, not significant (two-way repeated measures ANOVA). Plots show means ± SEMs

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