Fig. 5
From: Fear response-based prediction for stress susceptibility to PTSD-like phenotypes
Validation of the prediction model for stress susceptibility to PTSD-like behaviors. a-b Freezing responses during the fear generalization test. a Predicted-susceptible mice show increased freezing to a novel cue compared with that by unstressed control and predicted resilient mice (left). Predicted-susceptible mice show increased freezing responses to the CS compared with those by control mice but not predicted-resilient ones (right). b Predicted-susceptible mice show increases in generalization indices compared with those for control and predicted-resilient mice. **P < 0.01, ***P < 0.001, ****P < 0.0001, ###P < 0.001, ####P < 9 0.0001 (one-way ANOVA, Tukey’s test). c Predicted-susceptible mice show increased freezing responses during extinction training compared with those by unstressed control and predicted-resilient mice. **P < 0.01, ##P < 0.01 (two-way repeated measures ANOVA, Tukey’s test). d Predicted-susceptible mice exhibit enhanced freezing responses 24 h after extinction training compared with those by unstressed control and predicted resilient mice. ****P < 15 0.0001, ###P < 0.001 (one-way ANOVA, Tukey’s test). e ROC curves for predicted-susceptible and predicted-16 resilient mice. The AUC for the predicted-susceptible group is 0.7950 (95% confidence interval, 0.6884–0.9017; ****P < 0.0001) and that for predicted-resilient group is 0.7067 (95% confidence interval, 0.5845–0.8288; **P < 0.01)