Fig. 3
From: Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model
Ketamine inhibited the enhancement of high-gamma band power in CFA-treated rats. a Rats received either a ketamine or saline intraperitoneal injection. b Timeline for CFA, saline, and ketamine injections. c Example of trial-averaged LFP raw trace, in the chronic pain condition two days after saline injection. The panel directly below the raw trace shows trial-averaged time–frequency spectrum, with time 0 denoting the time of pinprick stimulation. d Example of trial-averaged LFP raw trace, in the chronic pain condition two days after ketamine injection. The panel directly below the raw trace shows trial-averaged time–frequency spectrum, with time 0 denoting the time of pinprick stimulation. e Z-score power in the theta frequency band (4–8 Hz) two days after saline or ketamine injection. f Z-score power in the alpha frequency band (8–15 Hz) two days after saline or ketamine injection. g Z-score power in the beta frequency band (15–30 Hz) two days after saline or ketamine injection (p = 0.0229, unpaired t-test). h Z-score power in the low-gamma frequency band (30–60 Hz) two days after saline or ketamine injection (p = 0.0267, unpaired t-test). i Z-score power in the high-gamma frequency band (60–100 Hz) two days after saline or ketamine injection (p = 0.0086, unpaired t-test). Error bars represent SEM. *p < 0.05; **p < 0.01