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Table 2 Peptides that are differentially expressed in CSF between neonatal HIBD and normal control

From: Peptidome analysis of cerebrospinal fluid in neonates with hypoxic-ischemic brain damage

Sequence Mass PI Protein names log2
(H/C)
P-value
Peptides up-regulated in HIBD (> 1.5 folds)
 GAGASSEP 978.6 3.85 Refilin-A (FAM101A) 2.7 1.59E−02
Peptides down-regulated in HIBD (> 1.5 folds)
 IAGYVTHLMK 1740.0 9.3 40S ribosomal protein S17 (RPS17) − 2.4 4.38E−06
 KIAFAITAIK 1987.3 10.81 40S ribosomal protein S18 (RPS18) − 2.9 2.07E−06
 YLYTLVITDKEK 2397.4 6.48 60S ribosomal protein L38 (RPL38) − 13.8 3.17E−06
 VAPEEHPVLLTEAPLNPK 2561.5 4.47 Actin, cytoplasmic 2 (ACTG1) − 2.2 1.90E−04
 TTGIVMDSGDGVTHTVPIYEGYALPHAILR 3791.0 5.36 Actin, cytoplasmic 2 (ACTG1) − 3.8 9.57E−07
 TTGIVLDSGDGVTHNVPIYEGYALPHAIMR 3804.0 5.36 Actin, gamma-enteric smooth muscle (ACTG2) − 4.7 2.00E−06
 VAPEEHPTLLTEAPLNPK 2867.7 4.47 Actin, gamma-enteric smooth muscle (ACTG2) − 3.0 1.40E−04
 FLSQPFQVAEVFTGHMGK 2646.4 7.55 ATP synthase subunit beta, mitochondrial (ATP5B) − 8.0 2.18E−08
 ISQMPVILTPLHFDRDPLQK 2955.7 7.55 GMP synthase [glutamine-hydrolyzing] (GMPS) − 2.5 5.19E−06
 SNYNFEKPFLWLAR 2392.3 9.3 GTP-binding nuclear protein Ran (RAN) − 6.1 1.47E−06
 IINEPTAAAIAYGLDKK 2699.6 6.49 Heat shock cognate 71 kDa protein (HSPA8) − 5.4 2.52E−08
 HSQFIGYPITLFVEK 2386.4 7.54 Heat shock protein HSP 90-alpha (HSP90AA1) − 4.6 2.79E−08
 HSQFIGYPITLFVEKER 2671.5 7.54 Heat shock protein HSP 90-alpha (HSP90AA1) − 3.1 1.01E−05
 NDEELNKLLGK 2183.3 4.43 Histone H2A.J (H2AFJ) − 7.1 2.47E−04
 VTIAQGGVLPNIQAVLLPK 2538.6 9.7 Histone H2A.J (H2AFJ) − 2.8 4.00E−03
 KTVTAMDVVYALKR 2506.5 10.24 Histone H4 (HIST1H4A) − 3.0 8.15E−05
 KTVTAMDVVYALK 2350.4 9.26 Histone H4 (HIST1H4A) − 6.2 1.81E−05
 VIQYLAVVASSHK 2022.2 9.3 Myosin-11 (MYH11) − 5.4 3.90E−04
 IVATKPLYVALAQR 2150.3 10.45 Polyadenylate-binding protein 3 (PABPC3) − 11.8 1.66E−05
 QILLYSATFPLSVQK 2315.4 9.3 Probable ATP-dependent RNA helicase DDX6 (DDX6) − 3.9 1.27E−05
 TLFVSGLPVDIKPR 2149.3 9.7 RNA-binding protein with multiple splicing 2 (RBPMS2) − 6.2 3.34E−09
 NILFVITKPDVYK 2461.5 9.26 skNAC (NACA) − 9.4 6.45E−07
 ILSGGLSYDTV 1166.6 3.75 Syntaxin-binding protein 5 (STXBP5) − 2.5 2.30E−04
 EMVELPLRHPALFK 2287.3 7.55 Transitional endoplasmic reticulum ATPase (VCP) − 5.8 1.11E−05
 LDHKFDLMYAK 2292.3 7.54 Tubulin alpha-1A chain (TUBA1A) − 7.3 5.37E−06
 MSATFIGNSTAIQELFKR 2620.5 9.7 Tubulin beta-2B chain (TUBB2B) − 4.5 1.12E−07
 YLTVAAIFR 1356.8 9.35 Tubulin beta-2B chain (TUBB2B) − 4.3 1.67E−06
 GPFGQIFRPDNFVFGQSGAGNNWAK 3391.7 9.7 Tubulin beta-2B chain (TUBB2B) − 10.7 3.87E−08
 KLAVNMVPFPR 1879.1 11.65 Tubulin beta-2B chain (TUBB2B) − 7.7 1.86E−07
 PFGQIFRPDNFVFGQSGAGNNWAK 3391.7 9.7 Tubulin beta-2B chain (TUBB2B) − 7.5 1.41E−07
 MAATFIGNSTAIQELFKR 2605.5 9.7 Tubulin beta-4A chain (TUBB4A) − 4.4 4.18E−07
 KEAESCDCLQGFQLTHSLGGGTGSGMGTLLISK 4351.3 5.54 Tubulin beta-4A chain (TUBB4A) − 2.7 4.90E−04
 LTDISVTDPEKYPHMLSVK 3083.7 5.52 U6 snRNA-associated Sm-like protein LSm2 (LSM2) − 4.2 5.40E−03
 GLLLLGHLTVDTY 1718.0 5.29 V-set and immunoglobulin domain-containing protein 4 (VSIG4) − 2.9 2.10E−04
  1. H: Peptide intensity (CSF of neonatal HIBD); C: Peptide intensity (CSF of normal controls)