Table 2 Peptides that are differentially expressed in CSF between neonatal HIBD and normal control
From: Peptidome analysis of cerebrospinal fluid in neonates with hypoxic-ischemic brain damage
Sequence | Mass | PI | Protein names | log2 (H/C) | P-value |
|---|---|---|---|---|---|
Peptides up-regulated in HIBD (>Â 1.5 folds) | |||||
 GAGASSEP | 978.6 | 3.85 | Refilin-A (FAM101A) | 2.7 | 1.59E−02 |
Peptides down-regulated in HIBD (>Â 1.5 folds) | |||||
 IAGYVTHLMK | 1740.0 | 9.3 | 40S ribosomal protein S17 (RPS17) | − 2.4 | 4.38E−06 |
 KIAFAITAIK | 1987.3 | 10.81 | 40S ribosomal protein S18 (RPS18) | − 2.9 | 2.07E−06 |
 YLYTLVITDKEK | 2397.4 | 6.48 | 60S ribosomal protein L38 (RPL38) | − 13.8 | 3.17E−06 |
 VAPEEHPVLLTEAPLNPK | 2561.5 | 4.47 | Actin, cytoplasmic 2 (ACTG1) | − 2.2 | 1.90E−04 |
 TTGIVMDSGDGVTHTVPIYEGYALPHAILR | 3791.0 | 5.36 | Actin, cytoplasmic 2 (ACTG1) | − 3.8 | 9.57E−07 |
 TTGIVLDSGDGVTHNVPIYEGYALPHAIMR | 3804.0 | 5.36 | Actin, gamma-enteric smooth muscle (ACTG2) | − 4.7 | 2.00E−06 |
 VAPEEHPTLLTEAPLNPK | 2867.7 | 4.47 | Actin, gamma-enteric smooth muscle (ACTG2) | − 3.0 | 1.40E−04 |
 FLSQPFQVAEVFTGHMGK | 2646.4 | 7.55 | ATP synthase subunit beta, mitochondrial (ATP5B) | − 8.0 | 2.18E−08 |
 ISQMPVILTPLHFDRDPLQK | 2955.7 | 7.55 | GMP synthase [glutamine-hydrolyzing] (GMPS) | − 2.5 | 5.19E−06 |
 SNYNFEKPFLWLAR | 2392.3 | 9.3 | GTP-binding nuclear protein Ran (RAN) | − 6.1 | 1.47E−06 |
 IINEPTAAAIAYGLDKK | 2699.6 | 6.49 | Heat shock cognate 71 kDa protein (HSPA8) | − 5.4 | 2.52E−08 |
 HSQFIGYPITLFVEK | 2386.4 | 7.54 | Heat shock protein HSP 90-alpha (HSP90AA1) | − 4.6 | 2.79E−08 |
 HSQFIGYPITLFVEKER | 2671.5 | 7.54 | Heat shock protein HSP 90-alpha (HSP90AA1) | − 3.1 | 1.01E−05 |
 NDEELNKLLGK | 2183.3 | 4.43 | Histone H2A.J (H2AFJ) | − 7.1 | 2.47E−04 |
 VTIAQGGVLPNIQAVLLPK | 2538.6 | 9.7 | Histone H2A.J (H2AFJ) | − 2.8 | 4.00E−03 |
 KTVTAMDVVYALKR | 2506.5 | 10.24 | Histone H4 (HIST1H4A) | − 3.0 | 8.15E−05 |
 KTVTAMDVVYALK | 2350.4 | 9.26 | Histone H4 (HIST1H4A) | − 6.2 | 1.81E−05 |
 VIQYLAVVASSHK | 2022.2 | 9.3 | Myosin-11 (MYH11) | − 5.4 | 3.90E−04 |
 IVATKPLYVALAQR | 2150.3 | 10.45 | Polyadenylate-binding protein 3 (PABPC3) | − 11.8 | 1.66E−05 |
 QILLYSATFPLSVQK | 2315.4 | 9.3 | Probable ATP-dependent RNA helicase DDX6 (DDX6) | − 3.9 | 1.27E−05 |
 TLFVSGLPVDIKPR | 2149.3 | 9.7 | RNA-binding protein with multiple splicing 2 (RBPMS2) | − 6.2 | 3.34E−09 |
 NILFVITKPDVYK | 2461.5 | 9.26 | skNAC (NACA) | − 9.4 | 6.45E−07 |
 ILSGGLSYDTV | 1166.6 | 3.75 | Syntaxin-binding protein 5 (STXBP5) | − 2.5 | 2.30E−04 |
 EMVELPLRHPALFK | 2287.3 | 7.55 | Transitional endoplasmic reticulum ATPase (VCP) | − 5.8 | 1.11E−05 |
 LDHKFDLMYAK | 2292.3 | 7.54 | Tubulin alpha-1A chain (TUBA1A) | − 7.3 | 5.37E−06 |
 MSATFIGNSTAIQELFKR | 2620.5 | 9.7 | Tubulin beta-2B chain (TUBB2B) | − 4.5 | 1.12E−07 |
 YLTVAAIFR | 1356.8 | 9.35 | Tubulin beta-2B chain (TUBB2B) | − 4.3 | 1.67E−06 |
 GPFGQIFRPDNFVFGQSGAGNNWAK | 3391.7 | 9.7 | Tubulin beta-2B chain (TUBB2B) | − 10.7 | 3.87E−08 |
 KLAVNMVPFPR | 1879.1 | 11.65 | Tubulin beta-2B chain (TUBB2B) | − 7.7 | 1.86E−07 |
 PFGQIFRPDNFVFGQSGAGNNWAK | 3391.7 | 9.7 | Tubulin beta-2B chain (TUBB2B) | − 7.5 | 1.41E−07 |
 MAATFIGNSTAIQELFKR | 2605.5 | 9.7 | Tubulin beta-4A chain (TUBB4A) | − 4.4 | 4.18E−07 |
 KEAESCDCLQGFQLTHSLGGGTGSGMGTLLISK | 4351.3 | 5.54 | Tubulin beta-4A chain (TUBB4A) | − 2.7 | 4.90E−04 |
 LTDISVTDPEKYPHMLSVK | 3083.7 | 5.52 | U6 snRNA-associated Sm-like protein LSm2 (LSM2) | − 4.2 | 5.40E−03 |
 GLLLLGHLTVDTY | 1718.0 | 5.29 | V-set and immunoglobulin domain-containing protein 4 (VSIG4) | − 2.9 | 2.10E−04 |