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Fig. 3 | Molecular Brain

Fig. 3

From: The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception

Fig. 3

σ2R promotes morphine-induced supraspinal analgesia. a Wild-type (WT) and σ2R−/− (KO) mice were icv injected with increasing doses of morphine, and antinociception was monitored at different intervals by the warm water (52 °C) tail-flick test. Each point is the mean ± SEM of groups of six mice. For every post-opioid interval, * indicates a significant difference compared to the group that received 10 nmol morphine. b Dose response curves of morphine in WT, σ2R−/− mice (left panel) and of antisense oligonucleotide-induced σ2R knockdown (KD) CD1 mice and controls treated with a mismatched oligodeoxinucleotide (RD-M; right panel). The analgesic effect was evaluated at point of the peak effect, i.e., 30 min after morphine injection. Each point is the mean ± SEM of groups of six mice. * Indicates a significant difference compared to the WT (RD-M) group. c Mice were icv injected with 3 nmol S1RA 20 min before treatment with 10 nmol (WT) or 30 nmol (KO) morphine, and analgesia was evaluated 30 min later. The points are the mean ± SEM of the data from six mice. For every postopioid interval, * indicates that S1RA produced a significantly different response than morphine only. All data were analyzed by pairwise Holm-Sidak multiple comparison tests following ANOVA; p < 0.05

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