Fig. 2

The Effects of anti-α2AP neutralizing antibodies on spatial memory. a Anti-α2AP neutralizing antibodies or control IgG were intracerebroventricularly injected in 12-week-old C57BL/6J mice after the first day of training in the MWM test. On the second day, mice were repeatedly trained, and then the probe tests were performed 30 min, 1 month and 3 months later. b The results of the training sessions. The latency to the target in each trial was measured. The values represent the mean values of 4 trials in each session. c–e The results of the probe tests at 30 min (c), 1 month (d) and 3 months (e) after training. The time in each quadrant was measured. The values represent the mean ± S.E. (control IgG: n = 10, α2AP Ab: n = 9). Statistical significance was evaluated using an ANOVA with an LSD post-hoc test. **P < 0.01, ns non-significant