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Fig. 6 | Molecular Brain

Fig. 6

From: α2-Antiplasmin as a potential regulator of the spatial memory process and age-related cognitive decline

Fig. 6

The effects of α2AP deficiency on age-dependent oxidative stress and neuroinflammation. a and b The levels of 13-HPODE-adducted protein relative to those of GAPDH in the hippocampus and cerebral cortex of young and old WT and α2AP−/− mice were determined by Western blotting (young mice: 11 weeks of age, old mice: 60 weeks of age). The relative intensity was measured using the NIH ImageJ software program and normalized to that of GAPDH. The bar graphs represent the mean ± SE (young WT mice: n = 5, young α2AP−/− mice: n = 4, old WT mice: n = 5, old α2AP−/− mice: n = 4). c The levels of IL-6 mRNA in the hippocampus were shown (young mice: n = 7, old mice: n = 5). Statistical significance was evaluated by an ANOVA with an LSD post-hoc test. *P < 0.05., **P < 0.01

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