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Fig. 2 | Molecular Brain

Fig. 2

From: AAV9-Retro mediates efficient transduction with axon terminal absorption and blood–brain barrier transportation

Fig. 2

Comparison of the transduction efficiency between rAAV9-Retro and rAAV2-Retro injected into the VTA. A, B rAAV2-Retro-CaMKIIa-EGFP and rAAV9-Retro-CaMKIIa-EGFP viruses can efficiently infect neurons when injected into the VTA sites. C–J The two viruses can infect the same upstream brain regions, including the PFC, MO, MSC and MRN. k Comparison of the total number of neurons projecting into the VTA using rAAV9-Retro and rAAV2-Retro. The data are shown as means ± SEM. Statistical significance of differences was set at P < 0.05. No statistical difference was found in the total number of neurons projecting into the VTA (10,770 ± 1394 for AAV2-Retro; 10,278 ± 1957 for AAV9-Retro. P = 0.8477). Scale bars = 200 μm for Fig A-B; Scale bars = 100 μm for figure C–J. VTA: ventral tegmental area; PFC: prefrontal cortex; MO: somatomotor areas; MSC: medial septal complex; MRN: midbrain reticular nucleus

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Molecular Brain

ISSN: 1756-6606