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Fig. 2 | Molecular Brain

Fig. 2

From: Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease

Fig. 2

Mutations generated in zebrafish sorl1. a Zebrafish (Dr) sorl1 wild type (WT) and null (R122Pfs) exon 2 sequences with the chromatogram showing the Sanger sequencing of the null allele. Both the DNA and amino acid sequences are shown. b Alignment of the WT and EOfAD-like (V1482Afs) zebrafish sorl1 exon 32 sequences, with the chromatogram showing Sanger sequencing of the EOfAD-like allele of sorl1. The human (Hs) SORL1 exon 32 region is also shown with the C1478* mutation site and the equivalent C1481 zebrafish codon highlighted in red. c A schematic of the zebrafish Sorl1 protein with the protein domains and mutation sites indicated. VPS10 vacuolar protein sorting 10 domain. LDLR low density lipoprotein receptor, EGF epidermal growth factor, FN fibronectin, TMD transmembrane domain, ICD intracellular domain, Hs Homo sapiens, Dr Danio rerio

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Molecular Brain

ISSN: 1756-6606