Skip to main content
Fig. 6 | Molecular Brain

Fig. 6

From: Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease

Fig. 6

Heterozygosity for an EOfAD-like mutation in sorl1 often results in changes to gene expression in the opposite direction to more complete loss of wild type sorl1 function. a–p LogFC of the genes making up the gene sets in each comparison of sorl1 mutants. Only the gene sets found to be significantly enriched in EOfAD-like/+ brains are shown. The colour legend indicates the magnitude of the logFC in the heatmaps (red is upregulation, blue is downregulation). Remarkable contrast is seen in the directional changes in gene expression between the heterozygous mutants and the transheterozygous mutants for KEGG_PROTEASOME and KEGG/HALLMARK_OXIDATIVE_PHOSPHORYLATION and gene sets in which oxidative phosphorylation genes are an important components (KEGG_HUNTINGTONS_DISEASE and KEGG_ALZHEIMERS_DISEASE, see Additional file 7)

Back to article page

Molecular Brain

ISSN: 1756-6606