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Fig. 6 | Molecular Brain

Fig. 6

From: The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury

Fig. 6

Schematic figure of microglia Hv1-mediated neuronal injury and motor deficits following SCI. The illustration shows that SCI leads to Hv1-dependent microglia activation which causes an increase in IL-1β and ROS production. Consequently, there is an increase in neuronal loss, white matter loss and motor dysfunction. Deficiency of Hv1 prevents microglia activation and thereby ameliorates IL-1β / ROS production, neuronal injury and resultant motor deficits seen following SCI

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