Skip to main content
Fig. 5 | Molecular Brain

Fig. 5

From: Neuregulin-1 inhibits CoCl2-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice

Fig. 5

NRG1 treatment reduced superoxide generation induced by microinjection of CoCl2 into the VH of mice. a Photomicrographs reveal the generation of superoxide in the DG (top panels), CA1 (middle panels), and CA3 (bottom panels) regions of the VH in the Saline, CoCl2, and CoCl2 + NRG1 groups. Increased superoxide generation of VH induced by microinjection with CoCl2 (1 µl-25 mM) was measured by fluorescence microscopy using the DHE dye. The mice were treated with NRG1 (50 ng/kg) for 5 days. Scale bar, 100 µm; inset, enlarged areas. Scale bar, 25 µm. b Bar graph summarizing the data in a (DG) (n = 8; *P < 0.05 versus the saline group; ##P < 0.01 versus the CoCl2 alone group). c Bar graph summarizing the data in a (CA1) (n = 8; ***P < 0.001 versus the saline group; ###P < 0.001 versus the CoCl2 alone group). d Bar graph summarizing the data in a (CA2) (n = 8; ***P < 0.001 versus the saline group; ###P < 0.001 versus the CoCl2 alone group)

Back to article page

Molecular Brain

ISSN: 1756-6606