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Fig. 6 | Molecular Brain

Fig. 6

From: Neuregulin-1 inhibits CoCl2-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice

Fig. 6

NRG1 attenuated CoCl2-induced apoptosis and cell death in SH-SY5Y cells. a TUNEL staining (red) showing the amount of apoptosis that occurred in cells treated with 100 µM CoCl2 and either PBS or 10 nM NRG1 for 24 h. DAPI (blue) was used as a counterstain. Scale bars, 20 µm. b Apoptotic cells are expressed as the percentage of TUNEL-positive cells relative to the number of DAPI-stained cells (n = 6; ***P < 0.001 versus the control group; ##P < 0.01 versus the CoCl2 alone group). c NRG1 (10 nM) attenuated cell death induced by 100 µM CoCl2 in SH-SY5Y cells. After 36 h, the degree of cell death was measured by LDH activity in the medium (n = 6; **P < 0.01 versus the control group; #P < 0.05 versus the CoCl2 alone group)

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Molecular Brain

ISSN: 1756-6606