Fig. 4
Mn-enhanced rat brain and regional signal intensity changes. a Following administration of MnCl2, there was a heterogeneous signal distribution, as shown in the coronal (left upper), horizontal (left bottom), and sagittal planes (right) of the rat brain. b–f Line graphs depict the means and standard errors for Mn-enhanced signal intensity in each brain region of the control (blue lines), Torin1 (red lines), and XL388 (black lines) rats. Five regions of Mn-enhanced signal intensity in MR images were analyzed and compared. Signal intensities in Torin1- and XL388-injected rats were lower than those in control (vehicle injected) rats. *P < 0.05; **P < 0.01. Data are presented as a mean ± SEM