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Fig. 3 | Molecular Brain

Fig. 3

From: Intrinsic braking role of descending locus coeruleus noradrenergic neurons in acute and chronic itch in mice

Fig. 3

Chemogenetic activation of descending LC-NAergic signaling inhibits chronic itch. a, b Effect of CNO treatment on scratching behavior in DCP-treated mice that had expressed hM3Dq in the SDH-projecting LC-NAergic neurons by injection of two AAV vectors into the SDH and LC as shown in Fig. 1a. The time course of scratching behavior (a: n = 7, *P < 0.05) and the summary of total scratching behavior (b: n = 7, ***P < 0.001). Behavior was measured for 5 h after saline or CNO (10 mg/kg, i.p.) administration. Data show the mean ± SEM

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