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Fig. 2 | Molecular Brain

Fig. 2

From: Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus

Fig. 2

Leptin controls KCC2 activity in rat hippocampal slices. a Box plots of ∆EGABA induced by leptin 100 nM (20 min) in control condition (Lep), in the presence of bumetanide 100 and 20 µM, or in the presence of VU0423271 (VU0, 10 µM). b Bar plots of the mean and standard error to the mean of the reversal potential of GABAA receptor-mediated postsynaptic currents (EGABA) in the indicated conditions. c Box plots of leptin action (100 nm, 20 min) on spike activity in the presence of Gabazine (GBZ, 5 µM), or in the presence of VU0423271 (VU0, 10 µM). #P < 0.05 and ###P < 0.01 when compared to pre-leptin values, two-tailed Wilcoxon paired test. *P < 0.05 and ***P < 0.001 when compared to leptin experiments, two-tailed Mann Whitney test

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