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Fig. 4 | Molecular Brain

Fig. 4

From: Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer’s disease

Fig. 4

Representative images of amyloid plaque, microglia, and astrocyte expression in App-KI mice. a Upper panel shows localization of Aβ (red), Iba-1 (green), and GFAP (blue) in the cortico-hippocampus of App-KI at 2–6 months age. These are followed by individual images of Aβ, Iba-1, and GFAP (from top to bottom). Bottom panels are representative higher-magnification images of activated microglia and GFAP-reactive astrocytes around Aβ plaques. These panels (Merge) show localization of Aβ (light blue), Iba-1 (green), and GFAP (red) in the cortico-hippocampus of App-KI at 2–6 months of age. b–d Adult neurogenesis in hippocampus of App-KI mice. b Representative images of DCX and Ki-67 expression. (Scale bar: 100 µm) c Quantitative data of DCX-positive cells. Expression levels were reduced in the hippocampus of App-KI mice. d Quantitation of Ki-67–positive cells. Ki-67-positive cells (arrowheads) were less abundant in hippocampus of App-KI mice. Data are presented as means ± SEM (n = 4). *p < 0.05 (t-test)

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