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Fig. 3 | Molecular Brain

Fig. 3

From: Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity

Fig. 3

Translin KO mice show unaltered mGluR-LTD and unchanged hippocampal protein levels of FMRP, but show deficits in NMDAR-dependent LTD. a Hippocampal slices from translin KO mice (n = 5; males) and wildtype littermates (n = 5; all males) displayed similar mGluR-LTD induced by bath application of 100 μM of DHPG for 10 min (two-way repeated measures ANOVA, F(1,8) = 0.08, p = 0.79). b Hippocampal extracts from translin KO mice (n = 6) and wildtype littermates (n = 6) had similar protein levels of FMRP (t-test, p = 0.36). Beta-tubulin was used as the loading control and the expression level was normalized to the level of wildtype littermates. Representative blots are shown on top of the graph. C. Hippocampal slices from translin KO mice (n = 7; 1 male, 6 females) showed deficits in NMDAR-dependent LTD induced by prolonged low-frequency stimulation (1 Hz, 15 min) compared to the wildtype littermates (n = 5; 3 males, 2 females) (two-way repeated measures ANOVA, F(1,10) = 5.342, p = 0.043). Representative traces before (black) and after (red) stimulation are shown on top of the graphs. Scale bars for traces 2 mV, 5 ms. ‘n’ refers to the number of mice used. Error bars reflect S.E.M

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