Fig. 10

Electrophysiological analysis of the hippocampus of protrudin-deficient mice. a Input–output relation for AMPA receptor–mediated synaptic responses in acute hippocampal slices of WT and PRT^–/– mice. FV, fiber volley. b Time course of LTP induced by tetanic stimulation. A train of high-frequency stimulation was applied at time 0. Representative traces (averaged 10 consecutive responses) in the inset are EPSPs obtained at the times indicated by the numbers in the main panel. c Ratio of LTP at 60 min after tetanic stimulation. The P value was determined with Student’s unpaired t test. d Time course of LTD induced by DHPG application for 5 min (black bar). e Expanded view of the portions of the curves outlined by the dashed lines in d. f Ratio of LTD at 60 min after the start of DHPG application. The P value was determined with Student’s unpaired t test. g Time course of synaptic depression induced by low-frequency stimulation. PP-1 Hz, paired-pulse stimulation (interpulse intervals, 50 ms) at 1 Hz for 15 min (black bar). h Expanded view of the portions of the curves outlined by the dashed lines in g. i Ratio of depression at 60 min after the end of the 1-Hz stimulation. The P value was determined with Welch’s t test. All data are means ± SEM, with 6–12 values indicating the number of slices examined (each slice was from a different mouse)