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Fig. 2 | Molecular Brain

Fig. 2

From: Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning

Fig. 2

General health and neurological screen of protrudin-deficient mice. a, b, Body weight (a) and body temperature (b) of male WT and PRT–/– (KO) mice at 12 to 17 weeks of age. c Grip strength. d Latency to fall in the wire-hang test. e, Scatter plot of body weight and wire-hang latency. f Latency of the first paw response in the hot-plate test of pain sensitivity. g Latency to fall from the rotating rod in the rotarod test for motor function. h Scatter plot of body weight and rotarod latency. i–l Movement speed (i), number of movements (j), number of slips (k), and latency to reach the goal (l) in the balance-beam test for coordinated movement and sense of balance. All data are means ± SEM (WT mice, n = 22 in a–h and n = 18 in i–l; PRT–/– mice, n = 17 in a–h and n = 10 in i–l). P values for differences between genotypes were determined by Student's t test (a, b, f), Wilcoxon rank sum test (c, d), ANCOVA (e, h), or two-way repeated-measures ANOVA (g, i–l). The results of all statistical analysis are provided in Additional file 1: Table S1

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