Fig. 4

Social interaction of protrudin-deficient mice. a–e Duration of contacts (a), number of contacts (b), duration of active contacts (c), mean duration per contact (d), and distance traveled (e) in the social-interaction test. f–i Mean number of particles calculated for each hour over 7 days (f) and averaged over the last 3 days (g) as well as mean activity level (A.U., arbitrary units) for each hour over 7 days (h) and averaged over the last 3 days (i) in the home-cage social-interaction test. Time points are indicated in Zeitgeber time (ZT). All data are means ± SEM (WT mice, n = 11; PRT^–/– mice, n = 8). P values for differences between genotypes were determined with Student's t test (a–e) or by two-way repeated-measures ANOVA (f–i). The results of all statistical analysis are provided in Additional file 1: Table S1