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Fig. 3 | Molecular Brain

Fig. 3

From: Frequency and methylation status of selected retrotransposition competent L1 loci in amyotrophic lateral sclerosis

Fig. 3

Comparison of the methylation of six selected RC-L1 loci by tissue and affected status. a Box-Whisker plots indicate the methylation status of the 5′ junctions of six RC-L1 loci (L1_chr1_p12, L1_chr22_q12.1, L1_chr6_q24.1, L1_chrX_p22.2, L1_chr6_p22.3 and L1_chr8_q24.22; see Table 1) in the cerebellum (Cer), motor cortex (MCX) and blood. The average methylation status of 5′ junctions of the RC-L1 loci in cerebellum, motor cortex and blood constituted 75%, 72%, and 91%, respectively. Number of RC-L1 5′ junctions analysed – Cer n = 22, MCX n = 33, blood n = 11 across 9 individuals (controls = 2, FALS = 2, SALS = 5). b Box-Whisker plots presenting the methylation status of the 5′ junctions of the six RC-L1 loci (see above) in the cerebellum of control individuals (n = 2), and FALS (n = 2) and SALS (n = 2) patients. The average methylation status of the 5′ junctions of the RC-L1 loci in control individuals, FALS and SALS patients amounted to 75%, 82% and 68%, respectively. 22 RC-L1 5′ junctions were analysed in the cerebella (controls n = 7, FALS n = 8, SALS n = 7). c Box-Whisker Plots presenting the methylation status of the 5′ junctions of the six RC-L1 loci (see above) in the motor cortex of control individuals (n = 2), and FALS (n = 2) and SALS (n = 5) patients. The average methylation status of the 5′ junctions of the RC-L1 loci in control individuals, FALS and SALS patients amounted to 96%, 63% and 70%, respectively. 33 RC-L1 5′ junctions were analysed in the motor cortices (controls n = 7, FALS n = 8, SALS n = 18). Two-tailed t-test ** p < 0.01, *** p < 0.001 X = mean

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