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Fig. 1 | Molecular Brain

Fig. 1

From: MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus

Fig. 1

Schematic representation of the experimental design and alternative splicing events analyzed in this study. The viral vector contains a U6 promoter driving expression of MeCP2-shRNA or a control-shRNA and mCherry expression under the CamKIIα promoter. Three weeks after the delivery of recombinant AAVs into the dorsal hippocampus, mice remained either in home-cage (Baseline) or trained in object location learning. 30 min after training mice dorsal hippocampi were micro dissected and RNA-seq and alternative splicing analysis was performed. bGH polyA bovine growth hormone polyadenylation signal, ITR inverted terminal repeat, WPRE Woodchuck Hepatitis virus post-transcriptional regulatory element

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