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Fig. 2 | Molecular Brain

Fig. 2

From: MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus

Fig. 2

Spatial learning induces alternative splicing events that are altered in MeCP2 knockdown mice. a Schematic representation of the comparisons used. b Proportion of each differential alternative splicing events (DAS) in control conditions (left) or in MeCP2 knock-down conditions (right) in learning-induced conditions. c Number of inclusion (positive ΔPSI, blue) and exclusion (negative ΔPSI, red) events for each type of alternative splicing modality in Control-shRNA (Control) and MeCP2-shRNA (MeCP2) mice (q-value < 0.05). d Pie charts showing the proportion of inclusion and exclusion events for intron retention (IR) and exon skipping (ES) in Control-shRNA and MeCP2-shRNA mice. e Scatter plots showing changes in IR and ES events in Control-shRNA (Control) and MeCP2-shRNA (MeCP2KD) mice upon learning. Red dots and blue squares represent alternative splicing events that occurred in either Control or MeCP2 knockdown hippocampi (q-value < 0.05), respectively. Green triangles represent alternative splicing events that occurred in both conditions (q-value < 0.05). f Violin plots showing the ΔPSI distribution of IR (left) and ES (right) events in Control-shRNA and MeCP2-shRNA hippocampi after learning. The P-values are based on paired two-tailed Student’s t test or Wilcoxon test and are indicated at the top of each panel. ΔPSI: delta “percent spliced in”

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