Fig. 3
From: MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus
Analysis of genes that underwent differential alternative splicing events upon spatial learning. a, b Schematic representation of comparisons used (top). Gene ontology (GO) analysis for genes that underwent differential alternative splicing in the dorsal hippocampi of Control-shRNA (a) and MeCP2-shRNA (b) mice upon learning. Enriched GO terms (Fisher’s exact test P < 0.001) for genes that underwent inclusion or exclusion (q-value < 0.05) events, upon learning. The blue and red bars represent − log10 (P-value) of the GO enrichment for inclusion and exclusion events, respectively. The vertical dashed line serves as a marker for P-value = 0.001 [− log10 (P-value) = 3]. Absence of a colored bar means that genes of that GO term were not enriched in that specific category. c Venn diagram showing overlap between total number of differentially expressed genes (DEGs) and genes that underwent differential alternative splicing events (DAS) in home-cage (baseline) conditions when MeCP2 was knocked down in the adult dorsal hippocampus. d Venn diagram showing overlap between total number of differentially expressed genes and genes that underwent differential alternative splicing events in learning state (learning) conditions when MeCP2 was knocked down in the adult dorsal hippocampus