Fig. 1
Oligodendrocyte lineage-specific Chd8 heterozygous mutant mice manifest microstructural changes in the brain. a Voxel-based analysis of fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) in Olig1-Cre/Chd8L+/F mice (mut) compared with Olig1-Cre/Chd8+/+ mice (ctl) (n = 12 mice per genotype). Five rostral-to-caudal axial T2-weighted structural images are overlaid with voxels that showed a significant difference (voxel-level P < 0.01, with a cluster-level FDR correction of P < 0.05). MO motor cortex, SS somatosensory cortex, ACA anterior cingulate cortex, CP caudoputamen, ac anterior commissure. b–e FA (b), MD (c), RD (d), and AD (e) values in the indicated regions of interest (ROIs) of Olig1-Cre/Chd8L+/F mice compared with Olig1-Cre/Chd8+/+ mice (n = 12 mice per genotype). Significantly altered clusters of each brain region in (a) were defined as ROIs. The ROI “ACA” also included retrosplenial cortex in addition to ACA. The ROI “SS” also included temporal association cortex in addition to SS. The ROI “ac” also included CP and nucleus accumbens (ACB) in addition to ac. Data are means + SEM. Uncorrected P values (Student’s t test) are shown together with asterisks (*P < 0.05, **P < 0.01, ***P < 0.001) indicating significance level after correction by the FDR. More detailed information for each cluster is provided in Additional file 1: Table S1