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Fig. 5 | Molecular Brain

Fig. 5

From: Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain

Fig. 5

Correlation of altered functional brain connectivity with brain structural and behavioral changes. a, b Correlation between the strength of functional connectivity (FC) for PL-CP (a) or PL-CA1 (b) and FA or RD values in CP (a) or fx (b) of Olig1-Cre/Chd8L+/F and Olig1-Cre/Chd8+/+ mice (n = 12 mice per genotype). c Correlation between total contact time in the reciprocal social interaction test and the strength of functional connectivity for PL-CA1 or PL-BLA. Pearson’s correlation coefficient (R) and uncorrected P values are shown, with * indicating P < 0.05 after correction by FDR. d Positive and negative correlations between the duration of social interaction and the strength of functional connectivity between the indicated brain regions are represented by red and blue lines, respectively (color shade reflects the correlation coefficient R). PL prelimbic cortex, ILA infralimbic cortex, ORB orbitofrontal cortex, DG dentate gyrus, CA1 cornu ammonis 1, SUB subiculum, BLA basolateral amygdala, CP caudoputamen, ACB nucleus accumbens, VTA ventral tegmental area, PAG periaqueductal gray. The correlation between the extent of functional connectivity in PL-CA1, PL-SUB, and ORB-BLA and social interaction survived FDR corrections. Correlation coefficients and statistical values are also provided in Table 2 and Additional file 2: Table S2. The results of rsfMRI processing without GSR are provided in Additional file 3: Fig. S5

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