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Fig. 4 | Molecular Brain

Fig. 4

From: Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel CaV3.1 caused by a mutation responsible for spinocerebellar ataxia

Fig. 4

Detailed analysis of the effect of efonidipine on mutant CaV3.1. a Steady-state activation curves with efonidipine. The activation curve of MT did not shift with the administration of efonidipine. Data are presented as the mean ± S.E.M. (WT efonidipine 0 [n = 10], WT efonidipine 5 µM [n = 16], MT efonidipine 0 [n = 10], and MT efonidipine 5 µM [n = 14]). b Comparison of the half-conductance of the activation potential. Data were obtained from the same cells shown in Fig. 3. There was a significant difference between WT and MT without efonidipine (p = 0.008). However, efonidipine did not affect the half-conductance of the activation potential of wild-type and the mutant CaV3.1 significantly (p = 0.695, 0.567, respectively). **p < 0.01, ns: not significant. c Comparison of the slope factor of the activation curve. No significant difference was observed between WT without efonidipine and each group (WT with 5 µM efonidipine, p = 0.550; MT without efonidipine, p = 0.200; MT with 5 µM efonidipine, p = 0.695)

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