Fig. 3

CCR2 is co-labeled with CGRP-expressing and IB4-binding terminals in superficial spinal dorsal horn and displays upregulation upon inflammation. a, b Immunofluorescence staining and quantitative summary showing an increase in CCR2-immunoreactivity in IB4-positive terminals in the ipsilateral (injured) dorsal horn at 24 h after CFA. c, d CCR2-immunoreactivity in CGRP-positive terminals are strongly increased in the ipsilateral (injured) dorsal horn at 24 h after CFA. Arrows indicate the co-expressing terminals. **P < 0.01, *** P < 0.001. Two-Way ANOVA followed by post-hoc Bonferroni test (n = 4 mice/group). Data are expressed as mean ± SEM