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Fig. 6 | Molecular Brain

Fig. 6

From: Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice

Fig. 6

Western blot analysis of PD related proteins in the striatum. a Striatal samples from 22-months-old NTg mice (n = 3) and Tg mice (n = 3) were tested for a variety of PD associated proteins: TH, α-synuclein, Phosphor-Tau (AT8), DAT and DD2R by Western blot. β-actin was used as a loading control. b Quantification analysis of proteins detected (mean ± SEM). There was no significant difference in the relative expression of TH (P = 0.500), α-synuclein (P = 0.886), AT8 (P = 0.831), DAT (P = 0.407) and DD2R (P = 0.532). Student’s t-test. c Striatal samples were tested for the mitochondrial proteins Tom20, Mfn2 (Mitofusin-2), and Drp1, and the autophagy-related protein LC3-II by Western blot. β-actin was used as a loading control. d Quantification analysis of proteins detected (mean ± SEM). There was no significant difference in the relative expression of Tom20 (P = 0.662), Mfn2 (P = 0.927), Drp1 (P = 0.283) and LC3-II (P = 0.210). n = 3. Student’s t-test

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