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Fig. 3 | Molecular Brain

Fig. 3

From: Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis

Fig. 3

The overlap between our FMRP target genes and genes associated with neurogenesis, ID, and ASD and their involvement in signaling pathways. a Venn diagram depicting the overlap of our FMRP target genes and neurogenesis genes retrieved from the MGI (GO: neurogenesis) and its top 10 GO. b Venn diagram depicting the overlap of our FMRP target genes and ID-associated genes retrieved from the OMIM (keyword: ID) and its top 10 GO. c Venn diagram depicting the overlap of our FMRP target genes and ASD-associated genes retrieved from the SFARI database. Statistical significance was determined by hypergeometric distribution analysis. d The 17 FMRP “core” target genes common in the four gene sets FMRP-IP, neurogenesis, ID, and ASD. e Signaling pathways in which the FMRP target genes were involved. The highlighted molecules were the identified FMRP “core” target genes (red) and other FMRP target genes in our data (green), which were involved in Ras/MAPK, Wnt/β-catenin, and mTOR signaling pathways

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Molecular Brain

ISSN: 1756-6606