Skip to main content

Table 1 Brain GABA and glutamate contents

From: Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice

  Contents (nmol/mg tissue) % Reduction t values p values
Gad1+/+ Gad1tTA/STOP−tetO
GABA      
 Frontal cortex 0.632 ± 0.027 0.462 ± 0.019 27.0 5.052  < 0.001
 Hippocampus 0.850 ± 0.033 0.546 ± 0.019 35.8 7.844  < 0.001
 Cerebellum 0.651 ± 0.026 0.281 ± 0.011 56.8 12.753  < 0.001
Glutamate      
 Frontal cortex 5.550 ± 0.112 5.617 ± 0.156 − 1.2 0.350 0.731
 Hippocampus 5.477 ± 0.148 5.479 ± 0.171 0.0 0.008 0.994
 Cerebellum 4.184 ± 0.086 4.356 ± 0.127 − 4.1 1.144 0.268
  1. Dox-treated Gad1+/+ (n = 10) and Gad1tTA/STOP−tetO (n = 9) mice were used to determine the brain contents of GABA and glutamate. Data represent the mean ± SE. % Reduction was calculated by 100 − [(the mean value of Gad1tTA/STOP−tetO mice)/(the mean value of Gad1+/+ mice)] × 100. A p value less than 0.05 was considered a significant difference (Student’s t-test)