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Fig. 1 | Molecular Brain

Fig. 1

From: Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

Fig. 1

Pitstop2 rescues mechanical allodynia in male CRMP2K374A/K374A knock-in mice with a spared nerve injury (SNI). Paw withdrawal thresholds of age-matched and genotyped WT and CRMP2K374A/K374A mice were measured at baseline and for six weeks following SNI. Post SNI, von Frey testing was confined to the sural nerve innervated region of the paw. a Time course showing that, at 42 days following SNI, male CRMP2K374A/K374A mice do not develop mechanical allodynia, which can however be precipitated by Pitstop2 administered by a lumbar puncture (2 µg in 5 µl) and followed over 3 h. *p < 0.05 two-way ANOVA with Sidak’s post hoc test. b Area under the curve for paw withdrawal thresholds was derived using the trapezoid method and calculated from day 42 until 3 h after injection (dashed box in panel a). Error bars indicate mean ± SEM. *p < 0.05 Kruskal–Wallis test. The experiments were conducted by an investigator blinded to the genotype and treatment (n = 5 each)

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