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Fig. 3 | Molecular Brain

Fig. 3

From: Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

Fig. 3

CRMP2-mediated decrease in sodium currents observed in DRGs from CRMP2K374A/K374A mice is rescued in cells lacking Numb. a Representative sodium current traces recorded from small-sized DRG neurons of WT and CRMP2K374A/K374A female mice, in response to depolarization steps from − 70 to + 60 mV from a holding potential of − 60 mV. b Summary of current density–voltage curves and c peak current density (pA/pF) from DRG neurons. Total sodium current density was significantly smaller in DRGs from homozygous mice vs. DRG neurons from WT + siRNA-Control (n = 11 and 13 cells/condition, p = 0.0428, Kruskal–Wallis test with Dunn’s post hoc), and vs. DRG neurons from CRMP2K374A/K374A + siRNA-Numb (n = 11 and 14, p = 0.0241, Kruskal–Wallis test with Dunn’s post hoc). d Boltzmann fits for normalized conductance G/Gmax-voltage relations for voltage dependent activation and inactivation of the sensory neurons. Half-maximal activation and inactivation (V1/2) and slope values (k) for activation and inactivation are presented in Table 1. There were no significant differences in V1/2 and k values of activation and inactivation between genotype and treatment (One-way ANOVA with Dunnett’s post hoc test). Error bars indicate mean ± SEM

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