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Fig. 1 | Molecular Brain

Fig. 1

From: Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150glued

Fig. 1

Dysbindin regulates axonal mitochondrial movement and density. a Representative kymographs of mitochondrial movement in DIV 10–12 primary cortical neurons of WT and Sandy mice. The movements of mitochondria in the proximal and distal axons are shown. A scale bar represents 20 μm. b Quantitative analyses of the motile fraction of mitochondria, and c anterograde and retrograde movements of mitochondria. d Quantification of mitochondrial density (the number of mitochondria per 100 μm) in the proximal and distal axons of DIV 10–12 primary cortical neurons (n = 9 axons for WT, n = 15 axons for Sandy, and n = 12 axons for Sandy + mDysbindin for the proximal axons, n = 15 axons for WT, n = 17 axons for Sandy, and n = 17 axons for Sandy + mDysbindin for the distal axons). All results are presented as the mean \(\pm\) SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 from one-way ANOVA with Bonferroni’s multiple comparison test

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